Molybdenum disulphide is the toughest friction modifier you can add to an engine or gearbox. It is also an EP lubricant and is used by engine and gear manufacturers during assembly.
As for ZDDP, this additive doesn't work until you have lost the oil film. By then, friction has risen to such a high level that the heat produced activates the zinc in the ZDDP. The zinc is NOT an EP lubricant. Do NOT rely on ZDDP to sustain your cam and lifter faces.
Also, ZDDP is often found on lifter faces in high amounts...undesirable.
Stick with moly. The bearings, rings and exhaust valve guides and stems will run cooler and you engine seals will last longer. Moly helps to reduce parasitic HP loss. Some engine tuners say they gain 5% HP from the use of moly.
You can reduce oil temperatures by as much as 10F. just by adding moly.
I would start with a good oil for breakin and ad moly to about 15% by volume. I'll not make an oil recommendation because I have no idea how your engine is set up, piston speed, piston FPM, clearances, combustion chamber pressures, etc. The Rotella sounds OK.....which VIS are you using? Don't be afraid to run it at 4000 RPM for short periods after the engine reaches running temperature.
Also, make sure the oil is not entrained with air. After a short run, shut down and check the dipstick for air/oil. I have always preferred an oil window in the pan to a dipstick.
Also, don't forget, moly in the V-drive can help as well. Moly can quiet a noisy gear set immediately. Also, the moly helps seals last longer.
Also, remember, you likely going to use some oil for the first 20 hours of operation. This is not a bad thing. Just keep an eye on oil temperatures and level.