049s are a MkIV head and will not work on a GenV block. There will be a mismatch in the cooling passages at the lifter valley side of the deck.
http://www.strokerengine.com
Click the link, go to the Big Block Chevy section and scroll all the way to the bottom and it will show you the difference between the cooling passages between a MkIV and a GenV.
I think I remember hearing about a company that might make a special head gasket that will adapt a set of MkIV heads to a GenV block, but the experts may wanna chime in on that one.